Nilotinib induced significantly higher and faster rates of major molecular response and complete cytogenetic response than imatinib when given as first-line therapy. Medscape Medical News
FDA officials discuss the how the current system for accelerated approval is not working well; new changes being proposed include the idea of approval straight after phase 1. Medscape Medical News
Mitotane combined with etoposide, doxorubicin, and cisplatin is more effective than mitotane plus streptozocin for advanced adrenocortical carcinoma, according to the first trial comparing regimens. Medscape Medical News
The safety and efficacy of sorafenib is examined in patients 70-years and older with advanced renal cell carcinoma. Journal of the National Cancer Institute
This review article discusses the evidence for neoadjuvant and adjuvant treatment approaches when surgery is chosen as the definitive therapy for high-risk prostate cancer. Expert Review of Anticancer Therapy